Fig. 1. Multiomics analyses identified HMB responsive targets in ethanol-treated myotubes. (A). Differentially expressed genes on transcriptomics and proteomics in myotubes treated with 100 mM ethanol for different times compared with responses in untreated myotubes. (B). Integrated network of transcriptome from ethanol-treated myotubes of HMB targets- mTORC1 signaling with nodes including mitochondrial dysfunction, p70S6k signaling, AMPK signaling, and senescence pathways connected via shared molecules.